Along most of its run the stream hugs Broad Mountain which contributes tributary waters and digs it deeper below the navigable floor of the valley.

It rises in the peaks flanking join of the two ridgelines in a saddle at Hometown, PA and terminates in the Lehigh River about two miles below the town of Nesquehoning, Pennsylvania in the shadow of Mount Pisgah from which several minor unnamed tributary streams descend adding their waters.

[4] It then continues to the northeast in a relatively narrow valley over its steepest stretch then flattens out and slows making its way through Nesquehoning, which is a right bank town.

The heavily forested, relatively steep slopes of Broad and Nesquehoning Mountains and the occasional culm piles characterize the land within the watershed.

The Nesquehoning Creek valley consists of some residential and industrial development, including a power plant, but was primarily a transit corridor.

The middle two lesser tributary rills noted previously join in one such containment pond in an old Broad Mountain strip mine just above Nesquehoning.