Nesreen was born in Aleppo, Syria to the Palestinian poet and author Yousef Tafesh from Safed and an Algerian mother.

[6] Nesreen's first act ever was in a biography series about Hulagu Khan when she was still studying at the Higher Institute for Dramatic Arts.

[11] While still in college, she was briefly engaged to the Syrian movie and TV director of Palestinian origin, Al-Mothanna Sobah.

[16] In 2014, Dima Bayaa, actress and co-worker at Sabaya, exposed Tafesh's affair with her ex-husband Taim Hasan, calling her a "homewrecker.

[18] On January 30, 2023, the Public Prosecution assigned Tafesh to the Sheikh Zayed District Office of Giza Governorate for issuing a bad check worth LE4 million.