This union was one of the first interdynastic marriages between the Kartlian and Kakhetian branches of the Bagrationi dynasty, holding sway over the two breakaway successors of the once united Kingdom of Georgia.

Levan of Kakheti eventually hung back, but allowed his son and heir, Prince Giorgi, to join Simon's army.

[1] After the Iranian army captured Simon in battle and sent for imprisonment at Alamut in 1569, Queen Nestan-Darejan found herself in a hostile environment in Kartli.

Alexander could not get at Simon, but he, the Georgian chronicle says, dishonored Nestan-Darejan and, "like a brigand", rode off bearing his half-sister's drawers high upon a lance.

She lived on to see the accession to the throne of her young grandson, Luarsab II, subsequently a Christian martyr and saint of the Georgian Orthodox Church, and died sometime after 1612.