Since 2017, Shufrych has been in the pro-Russian Eurosceptic political party Opposition Platform — For Life, which was outlawed in 2022 following the launch of the Russian invasion of Ukraine.

In 1996 and through 2007, Shufrych was a member of the Social Democratic Party of Ukraine (united) (SDPU(o)) which was headed by former President Leonid Kravchuk.

As part of the 2006 Ukrainian political crisis, Shufrych was appointed as Head of the State Emergency Service of Ukraine in the Second Yanukovych government.

On 23 November 2012, President Yanukovych dismissed Shufrych from the position of deputy secretary of the National Security and Defense Council of Ukraine because he was re-elected into parliament in the 2012 Ukrainian parliamentary election.

[6] Shufrych was present at negotiations on 21 June 2014 to discuss President Petro Poroshenko's peace plan, although it was unclear who he represented there.

[10] In the 2014 Ukrainian parliamentary election, Shufrych was again re-elected into parliament; this time after placing 11th on the electoral list of Opposition Bloc.

[14] On 18 February 2022 (a week before the Russian invasion of Ukraine began), during a panel show, Shufrych was physically assaulted and put into a headlock by journalist Yuriy Butusov [uk] after he refused to condemn Vladimir Putin's actions in the Donbas and Crimea.

From March to June 2022 during the initial months of the invasion, Shufrych's affiliated political party would be suspended, dissolved, and banned by Ukrainian government bodies, stemming from allegations of the OPZZh having ties to Russia.

[19] Several objects of outlawed Soviet and Russian paraphernalia (including military uniforms, medals, swords, and the ribbon of Saint George) were found during a search of Shufrych's residence.