[1] The station is located on the western edge of Neu-Isenburg at the end of Bahnhofstraße, about two kilometres from the city centre.

To gain an economic benefit from the railway, the citizens of Neu-Isenburg made numerous submissions to the Ministry of Finance of the Grand Duchy of Hesse in Darmstadt, which was then responsible for transport in the state.

The accounts of 1852/1853 noted that receipts amounting to 107 guilders and 15 Kreuzers had been taken for the transport of passengers, animals and baggage.

In order to improve the railway connection to the centre of Neu-Isenburg, a branch line, which was about 2.2 km long, was commissioned to the southern part of the town on 20 March 1902.

During the occupation of the Ruhr in 1923, Neu-Isenburg station was commandeered by French troops and could not be entered by Germans.

It consisted merely of a wooden hut for the sale of tickets and a plank crossing of the track, which ensured a reasonably safe entry and exit.

There was a major accident in the last days of 1945 when the dispatcher on duty left the signal box to go to a shelter in anticipation of an air raid.

In the early 1960s, Deutsche Bundesbahn decided to join the Frankfurt Rhine-Main region to the international motorail network.

The Regionalbahn RB 61 service (Dreieich Railway) runs Monday to Friday hourly between Neu Isenburg and Rödermark-Ober-Roden.

Trains ran from Neu-Isenburg to Narbonne in France, Alessandria and Verona in Italy and Villach in Austria.

The Bahnhof Ostseite (east side) bus stops are served by buses to Neu-Isenburg-Gravenbruch (OF-51), Langen (OF-91) and Dreieich-Offenthal (OF-92) The Bahnhof Westseite (west side) bus stops are served by buses to Terminal 1 of Frankfurt Airport (X17 X19), Hofheim im Taunus (X17), Dietzenbach (X18), Walldorf (X18), Obertshausen (X19), Dreieich-Sprendlingen (OF-67) as well as lines OF-52 and OF-53 to various destinations within Neu-Isenburg.

There is a restaurant, a kiosk and a travel centre and a motorail ticket office the station building.

The next two tracks are part of line 3601, which is used by long-distance passenger and freight trains and do not abut platforms at the station.