The original Neuqua Valley campus building was opened in August 1997, and was built to house 3000 students.

A third building that was completed around 2007, the Frontier Campus, allowed seniors to receive dual credit for classes from the College of DuPage.

[12] In 2013, US News ranked Neuqua Valley 563rd in their annual list of the top American public high schools.

The A wing contains Neuqua's Fine and Applied Arts, as well as industrial and consumer education classrooms and facilities.

The D wing contains Math, Computer Science, Foreign Language, Special Education (SPED) and Business classrooms.

The J wing holds all core academic classes, such as, Math, Science, English, Foreign Language, and Social Studies.

In September 2017, Neuqua was the first high school in the area to receive the National Blue Ribbon Award under then U.S. president Donald Trump.

On the first day of the 2015–2016 school year, a student allegedly wore a Confederate flag, sparking a mass social media response.

The school sponsors interscholastic teams for young men and women in basketball, cross country, golf, soccer, swimming and diving, tennis, track and field, volleyball, and water polo.

[20] An extensive intramural program is available, competing in many sports including basketball, bowling, and even ping pong.

The team ran under the name "Naperville XC Club" to avoid violating IHSA season limitation by-laws.

The pep band performs at all of the home basketball games for both genders and Special Olympics.

The Birkett Freshman Center has two gymnasiums, a weight room, and a rock climbing wall (given as a senior class gift in 2003).

The school sponsors numerous extracurricular clubs and organizations ranging from arts and academic to cultural and special interest.

While an entire list can be found at nvhs.ipsd.org,[26] the following are the most notable in terms of being chapters of a larger national movement: