2E3V, 2HAZ, 2VKW, 2VKX, 3MTR, 5AEA468417967ENSG00000149294ENSMUSG00000039542P13591P13595NM_001386289NM_001386290NM_001386291NM_001386292NM_001081445NM_001113204NM_010875NM_001311065NP_000606NP_001070150NP_001229536NP_001229537NP_851996NP_001074914NP_001106675NP_001297994NP_035005NP_001391651Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle.

Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system.

The two most notable are: NCAM exhibits glycoforms as it can be posttranslationally modified by the addition of polysialic acid (PSA) to the fifth Ig domain, which is thought to abrogate its homophilic binding properties and can lead to reduced cell adhesion important in cell migration and invasion.

A member of the NCAM superfamily, NCAM2 gene has been observed progressively downregulated in human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.

[12] For this reason, NCAM2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

Successful radio-immunolocalisation of metastases was demonstrated after giving injections of NCAM-binding 123J-UJ13a or 131J-UJ13a radio-immunoconjugates to children with neuroblastoma.