1DPK, 1DPQ, 1KUP, 1KUZ, 1M8O, 1S4W, 1TYE, 2K1A, 2K9J, 2KNC, 2MTP, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4Z7O, 4Z7Q, 5HDB, 4Z7N367416399ENSG00000005961ENSMUSG00000034664P08514Q9QUM0NM_000419NM_010575NP_000410NP_034705Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation.

Mutations that interfere with this role result in thrombasthenia.

[5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.