[5][6][7] Other causes include nerve or muscle degeneration, autoimmunity, toxins, medications, malnutrition, metabolic derangements, hormone imbalances, infection, nerve compression/entrapment, comprised blood supply, and trauma.

[3] Diseases of the motor end plate include myasthenia gravis, a form of muscle weakness due to antibodies against acetylcholine receptor,[13][14] and its related condition Lambert–Eaton myasthenic syndrome (LEMS).

[16] Muscular dystrophies, including Duchenne's and Becker's, are a large group of diseases, many of them hereditary or resulting from genetic mutations, where the muscle integrity is disrupted, they lead to progressive loss of strength and decreased life span.

This usually starts with the observation of bulk, possible atrophy or loss of muscle tone.

[25] Genetic testing is an important part of diagnosing inherited neuromuscular conditions.