The train services are operated by Deutsche Bahn, DB Regio Nordost, and Hanseatische Eisenbahn.

The station is located east of central Neustrelitz at kilometer 98.5 of the Berlin Northern Railway.

The line from Berlin reaches Neustrelitz from the south and, north of the station, it turns to the east.

[3] Plans for a railway line from Berlin to Stralsund via Neustrelitz, then the location of the court of the Mecklenburg-Strelitz, had been around since the 1850s.

In 1853, the Prussian king Frederick William IV of Prussia approved a private railway line between these cities.

Neustrelitz station building was built in a stately style since the city was the residence of the Grand Duke of Mecklenburg-Strelitz.

Even after the establishment of Deutsche Reichsbahn, the border between two division (with headquarters in Schwerin and Stettin, later Greifswald) ran through the station.

The station building was destroyed during the Second World War and only the ground floor remained and it was fitted with a temporary roof.

[8] With the change of traffic to diesel-haulage from 1969 to 1973, new large workshop was built at the Neustrelitz locomotive depot (Bahnbetriebswerk).

[11] As part of a model project, however, in collaboration with the state and the infrastructure manager, RegioInfra GmbH, four pairs of trains a day between the two cities have continued to be operated by Eisenbahngesellschaft Potsdam.

The closed facilities for freight are to the north of the platforms, where also a track connection between the main lines and the Neustrelitz Süd station.

The station building is located on the western side of the track, facing the centre of the city.

[13] The facilities of the locomotive depot are located a kilometre north of the station on the western side of the railway tracks.

After the Deutsche Bahn decided not to operate the workshop, it was taken over by Prignitzer Eisenbahn GmbH, which is a subsidiary of the Italian company Netinera.