The highway proceeds northwest through the town of Blue Diamond towards Spring Mountain Ranch State Park.
The highway crosses the Las Vegas Beltway and runs through the planned community of Summerlin.
SR 159 continues east to intersect Interstate 15 and then passes south of Downtown Las Vegas.
A portion of Charleston Boulevard was previously designated U.S. Route 95 Alternate to bypass Downtown Las Vegas.
Approximately 8.8 miles (14.2 km) of SR 159 in Red Rock Canyon was designated a Nevada Scenic Byway on June 30, 1995.