It runs northwest from State Route 88 near the California state line along Foothill Road to Genoa, and then turns east on Genoa Lane to end at U.S. Route 395.

From there, the route heads northwest with a gradual climb through the Sheridan area to meet SR 207 near Mottsville.

The route then continues north, winding along the foothills of the Carson Range until reaching the town of Genoa.

From there, SR 206 makes an immediate right at the intersection with Main Street to terminate at US 395 west of Minden–Tahoe Airport.

[2] However, in the renumbering, SR 206 was assigned to return to US 395 using Jacks Valley Road rather than Genoa Lane.