It runs from the California state line along Woodfords Road to U.S. Route 395 in Minden.

The road loosely follows the river and the Carson Valley on the western edge of communities of Centerville, Gardnerville Ranchos, and Minden where the highway ends at a Y junction with U.S. Route 395.

The trail's use diminished with the establishment of the First transcontinental railroad which was completed in 1869 and follows a path closer to modern Interstate 80 across the Sierra Nevada.

Woodsford Road first appears on state maps in 1934 as a gravel and graded highway.

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