As Virginia Street passes north under Interstate 580 (I-580) and US 395 freeway on the south end of Reno, the US 395 Bus.

The alternate route ends just north of here, at the intersection with Patriot Boulevard; US 395 Bus., however continues to follow Virginia Street northward.

Large retail stores, shopping malls and restaurants begin to line the sides of the business route.

After passing another interchange with I-580/US 395 and the junction with Kietzke Lane, the Reno-Sparks Convention Center can be seen along the east side of the road, along with larger casino properties and additional businesses as the route continues north.

Passing north of California Avenue, Virginia Street narrows down and reaches Downtown Reno.

State Route 430 begins as Virginia Street crosses North McCarran Boulevard (SR 659).

Roadside businesses taper off as the route travels north out of Reno, paralleling the Union Pacific railroad tracks heading towards northern California.

SR 430 was previously a much longer route, extending from the northern reaches of Reno all the way through Washoe City along Virginia Street and the Carson–Reno highway.

The US 395 designation was removed from Virginia Street and added to the new highway segmentally as new stretches of freeway were completed.

More of SR 430 was given to local control by 2008, when the northern terminus of the southern section was moved to Patriot Boulevard.