Neverness concerns a far-future world where interstellar travel is controlled by a group of mathematicians called pilots, because of their abilities to do the calculations needed for space travel, and posthuman or AI computer brains called "gods" rule much of the galaxy.
It follows the deeds of Mallory Ringess, a young pilot, as he travels through the universe and discovers secrets and strangeness.
He encounters a god, lives as a Neanderthal caveman, and eventually discovers that the lord of the pilots' order is thousands of years old and immortal, and that enlightened aliens have hidden profound secrets in humanity's genes.
Zindell has said that it was partly based on Le Morte d'Arthur, with the pilots as "knights zipping around the universe in search of the Holy Grail".
[1] Mark Spencer praised the book for its unusual approach to showing an unfamiliar world, and the complexity of its story.