The depot was designed in the Colonial Revival style and includes walls of light brown brick, hipped roof with gabled dormers and a deep cornice with dentil molding at its base.

[21][22] In addition to New Jersey Transit bus operations and Rutgers Campus buses, the station is served by local shuttles known as Brunsquick and DASH.

[23][24] New Brunswick is one of nine cities in New Jersey designated as eligible for Urban Transit Hub Tax Credits by the state's Economic Development Authority.

[26][27] The Gateway is one such project located just to the north of station[28] and connected by a new pedestrian bridge, creating a direct link to the Rutgers campus.

[30][31] Another planned building, a 16-story residential tower at Somerset Street[33][34] located one block north of the station, is the second UTHTC-approved project in the city.

[35] In August 2011, the United States Department of Transportation obligated $450 million to a six-year project to improve 24 miles (39 km) of the Northeast Corridor between New Brunswick and Trenton.

[37] On October 13, 2023, Amtrak announced that the New Brunswick station, along with Princeton Junction, would receive upgraded service due to increased demand.