Route 108 is a highway in New Brunswick, Canada; running from Trans-Canada Highway exit 75 near Grand Falls to Route 8 exit 163 at Derby Junction (near Miramichi); a distance of 202.9 kilometres.

Route 108 follows an access road built in 2003 to the former Trans-Canada Highway, then runs southeast along its old alignment to the edge of the town of Grand Falls.

Route 108 continues southeast through Drummond and New Denmark, Blue Bell and Hazeldean.

Route 108 runs east passing the northern terminus of Route 390 from Tobique Valley on the Plaster Rock-Renous Highway, a 137-kilometre road, completed in the late 1960s, through entirely uninhabited forest land that is mostly owned by J.D.

There are no facilities or public buildings along the route, and signs warn of "winter conditions".