Within Fredericton, the highway is known as Riverside Drive in the district of Barkers Point and Union Street in Devon.

The Nashwaaksis area is bypassed by a four-lane divided expressway known as Ring Road, which connects to the Westmorland Street Bridge.

[1] West of Fredericton, Route 105 continues along the east bank of the river, through Douglas and Keswick Ridge, crossing the Mactaquac Headpond.

Between Mactaquac and Nackawic-Millville, the road was rerouted after construction of the dam and passes through areas such as Bear Island.

Continuing north along the river's east bank, Route 105 passes through Hartland, Florenceville, Bristol, Bath and Perth-Andover.