The New Castle District is a railroad line owned and operated by the Norfolk Southern Railway in the U.S. states of Ohio and Indiana.
Its south end is at Evendale, where it meets the Dayton District and Indiana and Ohio Railway's Oasis Subdivision.
It runs along a piece of CSX Transportation's Toledo Subdivision from Hamilton north to New Miami, Ohio using trackage rights.
Later that year, the Cincinnati, Logansport and Chicago Railway opened, extending northwest from Richmond, Indiana to New Castle.
The Fort Wayne, Muncie and Cincinnati Railroad became part of the Nickel Plate, absorbed by the Norfolk and Western Railway in 1964.