The club has taken part five times in international competitions organized by CONCACAF, the governing body of the sport in North America and the Caribbean.

In 2022, they lost to Pumas UNAM in penalty shootout after winning the first leg 3–0, which was only the second time in the tournament's history that a team failed to advance after securing that scoreline in the first match.

[2] In the second leg, played on March 26, goals from Taylor Twellman, Wolde Harris, and Steve Ralston brought the aggregate score within one.

The comeback was put to a stop when Alajuelense substitute Rolando Fonseca scored and the Revolution's Shalrie Joseph and Daniel Hernández were sent off.

[5] On the March 9 away leg in Alajuela, Alajuelense's Carlos Hernández scored a 90th minute free-kick, which sealed a 1–0 result and the Revolution's elimination.

The Revolution was scheduled to play Cavaly AS of Haiti in the Round of 16, although this matchup was cancelled after the Haitian side failed to secure visas.

[20][21] As of April 2024[update] The North American SuperLiga was an eight-team competition between MLS and Liga MX teams held initially in 2007.

[26] In the group stage, the Revolution hosted two Liga MX teams at Gillette Stadium, Santos Laguna and Pachuca CF, winning both games 1–0.

[29] In the semifinals, the Revolution defeated CF Atlante 1–0 in a heated match where four players received red cards.

[33] The followed this up with two more home matches in the group stage: a 1–1 draw against the Kansas City Wizards[34] and a 1–0 win over Club Atlas.

In the group stage, they defeated each of Pumas UNAM,[37] the Chicago Fire,[38] and Atlético Morelia in 1–0 matches at Gillette Stadium.

[41] This would be the last SuperLiga match before the tournament's cancellation, which made the Revolution the sole MLS team to have won the trophy.

[45] In the 2023 edition, the Revolution advanced from the group stage with a 0–0 draw against the New York Red Bulls,[46] and a 5–1 win against Atlético San Luis.

[47] After their last group stage match, the Revolution announced that head coach Bruce Arena had been put on administrative leave for inappropriate conduct.

[50] In the 2024 edition of the tournament, the Revolution were drawn in a group with Mazatlán and Nashville SC, with both of their games to be played at Gillette Stadium.