Route 161 is a state highway in Clifton, New Jersey, United States, running along Clifton Avenue between Allwood Road (County Route 602 or CR 602) and Van Houten Avenue (CR 614).

A short distance after, Route 161 provides a connector to Richfield Terrace on the northbound side of the highway, the park's divider known as Cross Street.

The highway continues northward, intersecting with Richland Court, which provides access to local residential homes.

Soon after, Route 161 intersects with Saint Andrew's Boulevard, which also serves as the northern terminus of Richfield Terrace and connects the highway with CR 609 (Mount Prospect Avenue).

Just past Saint Andrew's Boulevard Route 161 passes through a largely commercial section of Clifton with a heavy concentration of medical offices before terminating at an intersection with CR 614 (Van Houten Avenue).