State Road 181 (NM 181) is a 11.8-mile-long (19.0 km) state highway in the US state of New Mexico.

NM 181's southern terminus is at Interstate 25 Business (I-25 Bus.)

in Truth or Consequences, and the northern terminus is at the end of state maintenance north of Truth or Consequences.

The entire route is in Sierra County.

Media related to New Mexico State Road 181 at Wikimedia Commons