The highway begins at the junction with NM 28 in San Miguel, right across from the United States Post Office building.

The road heads northeasterly for 1.05 miles (1.69 km) through pecan orchards and fields of Mesilla Valley before turning east.

The road continues east through agricultural areas and at 2.04 miles (3.28 km) again turns northeast before reaching the community of Mesquite.

In 1930s NM 28 was extended to Mesilla, and the highway section lost its designation as a state road.

In 1988 the New Mexico Department of Transportation (NMDOT) went through a radical road renumbering program, and this stretch was designated as NM 192.