The road heads east-northeast through pecan orchards and fields of Mesilla Valley and after approximately 0.86 miles (1.38 km) crosses the Rio Grande river over a 475.7-foot-long (145.0 m) bridge, built in 1941.

Approximately one mile (1.6 km) farther, NM 226 reaches the western outskirts of the community of Berino.

NM 226 crosses railroad tracks of El Paso Subdivision of BNSF Railway right before reaching its eastern terminus at intersection with NM 478.

The section occupied by modern day NM 226 was constructed in the early 1940s as one of the spurs connecting NM 28 with agricultural communities lying along U.S. Route 85 (US 85).

[2] The entire route is in Doña Ana County.