State Road 300 (NM 300) is a 6.605-mile-long (10.630 km) state highway in the US state of New Mexico.
NM 300's southern terminus is at Interstate 25 (I-25), U.S. Route 84 (US 84), US 85 and US 285 south of Santa Fe, and the northern terminus is at NM 466 in Santa Fe.
The entire route is in Santa Fe County.