New Mexico State Road 45 (NM 45) is a 22.918-mile-long (36.883 km) State Highway in the US state of New Mexico that runs parallel to the Rio Grande from the Pueblo of Isleta, through Albuquerque, and to the Southern boundary of Rio Rancho.

Throughout most of Albuquerque, NM 45 is called Coors Boulevard.

Coors Boulevard serves as a major expressway in Albuquerque as it allows access to Interstate 40 (I-40), and other major highways in the city such as NM 423 (Paseo Del Norte), NM 528 (Alameda Boulevard), and NM 500 (Rio Bravo Boulevard/Sen.

Until 2012, the northernmost portion of this route traversed Old Coors Road between Coors Boulevard and Central Avenue (Historic U.S. Route 66).

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