State Road 527 (NM 527) is a 16.922-mile-long (27.233 km) state highway in the US state of New Mexico.

NM 527's western terminus is at the end of Route at Simms Mesa Campground, and the eastern terminus is at U.S. Route 64 (US 64) east of Blanco.

The entire route is in Rio Arriba County.

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