[2] The school is supported in part by the Foundation for Science and Mathematics Education, a 501(c)(3) nonprofit organization that advocates for "an open-admissions, rigorous, hands-on educational model paired with the belief that any student can succeed when provided with a safe and supportive environment.

From its inception until Hurricane Katrina, the school was housed on the campus of Delgado Community College.

Due to the damage Delgado received from Katrina, NOCSMHS moved to the building which housed the former Henry W. Allen Elementary School in the uptown New Orleans neighborhood.

In April 2018 the board for Sci High selected former Delgado Community College employee Monique Cola as the school's headmaster; she has a PhD from Tulane University.

[5] Katherine Hart of the Mid-City Messenger described it as "the only New Orleans public school built specifically for STEM education.