[1] District 66 is located in southwestern Manhattan, comprising the neighborhood of Greenwich Village, Tribeca, SoHo, NoHo,as well as a small portion of Battery Park City and the Meatpacking District.

The district includes City Hall, Washington Square Park, Union Square, the Stonewall Inn and the main campus of New York University.

Following Cynthia Nixon's unsuccessful gubernatorial primary campaign, arrangements had to be made for the Working Families Party to endorse the Democratic nominee, Andrew Cuomo.

This was due to election laws (at the time) that required Nixon to run for a different office, since the party had endorsed her prior to the September primary.

Nixon and WFP leadership chose to run in this district, where she lives.