It begins in the town of Hempstead at an intersection with NY 106 in North Bellmore that also serves as that route's southern terminus.

NY 105 proceeds east along the two-lane Jerusalem Avenue, paralleling the Southern State Parkway as it travels through a commercial section of North Bellmore.

After 1 mile (1.6 km), the road widens slightly to include a center turn lane.

Within Oyster Bay, the road runs across the northern edge of Massapequa before meeting NY 107 in a commercial district located a short distance from the town line.

A total of 7.09 miles (11.41 km) of highway were rebuilt as part of the $81,000 project (equivalent to $2.75 million in 2025), including the state-maintained section of modern NY 102.