The route heads northward as North Main Street, proceeding along the eastern base of the valley as it passes through the northern half of the community.

The route leaves the community and its residential surroundings after 0.75 miles (1.21 km), but retains the Rochester Street name until it reaches the Livingston–Monroe county line west of Honeoye Falls.

Past Monroe Street, the route makes a long, significant turn to the west, following Honeoye Creek into the town of Rush and the hamlet of the same name.

The highway meets Rush–West Rush Road at an intersection south of the community, at which point NY 15A turns back to the north and crosses over Honeoye Creek.

In the process, NY 15A becomes East Henrietta Road, a name the highway retains until its northern end in Rochester.

The surroundings initially remain as rural as they were in Rush; however, the amount of development along the highway gradually increases as the route approaches and passes over the New York State Thruway (I-90).

Once in the city, the route passes by two large office campuses south of Westfall Road and several blocks of homes north of the street before merging back into NY 15 (Mount Hope Avenue) at a junction east of Strong Memorial Hospital.

In 1926, only two sections of the route were state-owned: from Monroe Street west of Honeoye Falls north to Rochester, and the segment of highway in Livonia that modern NY 15A shares with US 20A.

[11][12] NY 2 was replaced in April 1939 by US 15, which was extended northward from its previous terminus at the Pennsylvania state line to Rochester.