Past Hamburg, NY 75 connects to the New York State Thruway (Interstate 90 or I-90) northwest of the village before ending a short distance from Lake Erie.

The portion of NY 75 south of Hamburg is a two-lane rural highway; in contrast, the section north of the village is four lanes wide and serves commercial and residential areas.

The origins of NY 75 date back to 1930 when New York State Route 62 was assigned to an alignment extending from Great Valley to Buffalo via Hamburg and Athol Springs.

It initially heads northeastward as the two-lane Sisson Highway, serving a handful of homes on the northern edge of the community prior to entering an open area dominated by farmland.

About 0.5 miles (0.8 km) from NY 39, the road curves northward, taking on a due north alignment as it heads across the rolling terrain that comprises most of northern Collins.

Development along the highway quickly rises in density from a large farm and a pocket of homes at the start of the concurrency to a series of residential streets across the town line that make up the hamlet of Water Valley.

The influx of homes brings US 62 and NY 75 across the main channel of Eighteenmile Creek and into the village of Hamburg, where the highway changes names to Pierce Avenue.

Continuing on, the highway remains four lanes wide but serves primarily residential areas located in and around Athol Springs, a hamlet on the shores of Lake Erie.

On the other side of the overpasses, NY 75 curves northeastward as it becomes Saint Francis Drive, leaving Camp Road to continue northwestward to the lake as a two-lane street.

The route continues on, passing south of Saint Francis High School before ending shortly afterward at a partial interchange with NY 5.