Running along the northern end of the village, NY 226 proceeds east along Mud Creek, before turning northeast, becoming a two-lane rural roadway.

[3] A short distance later, NY 226 leaves Savona for the town of Bath once again, dropping the Lamoka Avenue moniker and running along Mud Creek to the northeast.

[3] After crossing into Schuyler County, NY 226 continues northeast, passing south of Mill Pond as a two-lane rural roadway.

The route continues a northeastern wind for several miles through Schuyler County, entering the town of Tyrone, where it intersects with the western terminus of CR 22 a short distance from the shore of Lamoka Lake.

NY 226 continues north through Tyrone, running alongside a pond before bending east at an intersection with Kendall Hill Road.

[3] NY 226 was assigned as part of the 1930 renumbering of state highways in New York to the portion of its modern alignment northeast of Savona.