[4] After CR 299, NY 270 bends northwest along Campbell Boulevard as the two-lane residential street through Amherst, with the residences becoming less dense as the route proceeds north.

Large fields begin to surround NY 270 through Amherst as the route bends northeast into an intersection with CR 2 (Tonawanda Creek Road).

Just east of that intersection is the Duane B. Rodke Memorial Athletic Field, where NY 270 crosses over Tonawanda Creek via a truss bridge.

Now in the Niagara County town of Pendleton, NY 270 intersects with CR 60 (North Tonawanda Creek Road).

Through Pendleton, the route remains rural, passing homes and large fields as it proceeds north.

In the vicinity of Eggertsville, the route was reconfigured to follow Bailey Avenue and Grover Cleveland Highway between Main Street and Eggert Road.

[8][9] By 1935, NY 270 was realigned to bypass North Forest and Stahl Roads by way of a new section of Millersport Highway.

[18][19] The change was intended to eliminate truck traffic on Upper Mountain Road while providing additional capacity to NY 93.

[22] NY 270's intersections with Tonawanda Creek Road (Erie CR 2) and Tonawanda Creek Road North (Niagara CR 60) on the north and south approaches to the bridge were reconstructed as part of the $10.9 million project.

The new bridge is similar to the former, two-lane structure; however, unlike the old one, it has wide shoulders for bicyclists and includes new sidewalks for pedestrians.