The section between its southern terminus at U.S. Route 62 (US 62) and the Eggert Road intersection is named Grover Cleveland Highway.

The south end of NY 263 is at Bailey Avenue (US 62), a short distance north of the Buffalo city line in Amherst.

It soon crosses two of the northern Buffalo area's important arteries, Sheridan Drive (NY 324) and the Youngmann Expressway (I-290).

[4] The stores that have been almost continuously lining the road abate shortly after the interstate when it makes its only deviation from its straight course, curving around the north campus of SUNY Buffalo, where it was relocated in the early 1970s.

Past the campus and a nearby office park, the road narrows to two lanes in the small suburban hamlet of Getzville, where NY 270 heads due north as Campbell Boulevard.

At this junction, it turned one final time to follow Hunts Corners–Akron Road east to NY 93 near Akron.