It heads northeast as the two-lane East State Street Extension, passing by a line of homes as it leaves the Gloversville area.

After one-half mile (0.8 km), the number of residences surrounding the route begins to dwindle as the highway enters more rural areas.

[5] Past Dennies Crossing, the highway takes on a slightly southeastern alignment into the town of Mayfield, where it traverses progressively less developed and more forested areas.

A contract to improve the 2.01 miles (3.23 km) of modern NY 349 between CR 154 and the former Fonda, Johnstown and Gloversville Railroad was awarded on September 1, 1906.

[12] The portion of the route south of Mayfield became the northern half of NY 148, a new north–south highway that continued past Fonda to Central Bridge.