The western terminus of NY 382 was at an intersection with Bay State Road and NY 17 in the now abandoned hamlet of Red House, located 5 miles (8.0 km) southwest of the city of Salamanca in the town of Red House.

NY 382 paralleled Red House Brook east to the Allegany State Park boundary, where the NY 382 designation ended and the highway continued east as Allegany State Park Route 2.

[2][3] The route remained intact until the construction of the Southern Tier Expressway (STE) through Red House in the late 1960s and early 1970s.

Unwanted tourism in Jimerson Town, a newly built settlement northeast of Red House, prompted Seneca leaders to seek ways to reduce through traffic in the settlement; to do so, the state built a trumpet interchange off the expressway where NY 382 used to be, which, coupled with the flooding of the roadway of old Route 17 to the west, effectively cut Jimerson Town off from the highway system.

When the interchange at exit 19 of the STE was constructed c. 1970,[8] NY 382 was disconnected from Allegany State Park Route 2, which was realigned to meet the new exit (as was Bay State Road, much of which was moved to a route south of and parallel to the expressway).