Still a two-lane residential road, the route begins paralleling the CSX West Shore Line as it enters the hamlet of Hamburg.

After CR 53, NY 385 becomes a wooded roadway, soon bending eastward along the riverbanks into the village of Athens, where it gains the Washington Street moniker.

Near a junction with River Road, the route drops the North Washington Street moniker as it crosses back into the town of Athens.

At the intersection with Sunset Boulevard, the route turns northward, reaching a junction with Mansion Street.

Crossing under the West Shore Line, NY 385 enters downtown Coxsackie, becoming the main street through the village.

The company that ran the turnpike was in business for over a hundred years, until the road was sold to Greene County in 1910.

[7][8] In 1927, the segment of NY 10 south of Albany was redesignated as the New York portion of U.S. Route 9W following the creation of the U.S. Highway System.