The route begins to wind eastward as it enters the hamlet of Shutters Corners, bending southeast through the town of Wright.

The route crosses CR 1 (Switz Kill Road) and skirts the northern edge of Town of Berne Park.

Crossing through a wooded section of New Scotland, NY 443 soon bends southeast, reaching the northern terminus of CR 312 (Clarksville South Road).

After a short distance east, through the residential neighborhood of New Scotland, intersecting with the western terminus of CR 301 (Tarrytown Road), which eventually becomes NY 396 in Bethlehem.

Continuing east along Delaware Turnpike, NY 443 leaves the residential area, returning to the dense woods in New Scotland.

The route bends northward and crosses into the town of Bethlehem, changing names to Delaware Avenue.

[4] After crossing CR 52, NY 443 continues northeast along Delaware Avenue, entering the hamlet of Delmar.

Near Euclid Avenue, the route begins to parallel the Normans Kill, crossing under the New York State Thruway (I-87) just east of the latter's exit 23.

[4] NY 443 and US 9W continue northeast along Delaware Avenue, running along the western edge of Lincoln Park, crossing into the Capitol Hill section of Albany.

[citation needed] It was probably a few years before 1787 when Stephen Van Rensselaer III had it upgraded and straightened slightly to make it accessible by wagons.

[citation needed] Before that the settlers in the Beaver Dam as the Town of Berne is now known, had to go by way of the wagon road from Altamont, through what is now Knox, to the Schoharie Valley.

[5] NY 43 was truncated on its western end in the early 1970s to Rensselaer, a city bordering Albany on the eastern bank of the Hudson River.