As NY 146 reaches the hamlet of East a short time later, it meets CRs 252, 260, 261, and 262 in quick succession.

NY 146 continues eastward, passing through a rural area of Albany County on its way to the town of Guilderland and the village of Altamont contained within.

The route progresses onward, intersecting CRs 201 and 202 and passing over the CSX Transportation-owned Selkirk Subdivision railroad line and Normans Kill before meeting US 20 at Hartmans Corners.

[3] At the county line, Fort Hunter Road (CR 71) leaves to the left just before an interchange with the New York State Thruway.

[3] Here, maintenance of the route shifts from the New York State Department of Transportation (NYSDOT) to the city of Schenectady.

[3] Upon crossing into Niskayuna, ownership of the route shifts to Schenectady County, which maintains the roadway as CR 159.

[4] 3.5 miles (5.6 km) north of Union Street, NY 146 crosses over the Mohawk River on the Rexford Bridge and enters Saratoga County.

[5] The route turns eastward three-quarters of a mile (1.2 km) later at a junction with Glenridge Road (unsigned NY 914V) and CR 110.

NY 146 veers northward at this junction, then breaks eastward a mile (1.6 km) later at an intersection with CR 1345 southwest of Mechanicville.

[1] In Schenectady, NY 146 was originally routed on Union, Jay, and Nott Streets and Van Vranken Avenue through the northern portion of the city.

[13] In Halfmoon, NY 146 was initially routed on Pruyn Hill Road and South Street in the vicinity of Mechanicville.

To the south, the Rexford Bridge over the Mohawk River and the surrounding roadway will be improved in stages, with completion expected by 2017.