U.S. Route 62 (US 62) is a part of the U.S. Highway System that travels from the United States–Mexico border at El Paso, Texas, to Niagara Falls, New York.

In the U.S. state of New York, US 62 extends 102.77 miles (165.39 km) from the New York–Pennsylvania border south of Jamestown to an intersection with New York State Route 104 (NY 104) in downtown Niagara Falls, bypassing the city of Jamestown and serves the cities of Buffalo and Niagara Falls, along with several villages.

While NY 60 heads northwestward to serve Stillwater and the city of Jamestown beyond it, US 62 turns east and enters the town of Carroll upon crossing the Conewango Creek.

[8] The route continues on, paralleling Conewango Creek through the towns of Carroll and Poland to an interchange with the Southern Tier Expressway (Interstate 86/NY 17) southeast of the hamlet of Kennedy.

Here, NY 394 continues eastward along the banks of the creek while US 62 heads northward through a small valley surrounding Indian Brook and into the town of Ellington.

[9] Upon entering the town of Leon, US 62 veers slightly northeastward to run along the base of a small valley surrounding Mud Creek.

[9] Past Dayton, the valley becomes much less defined as the route follows a small stream through the town of Persia and into the village of Gowanda.

The routes turn northward at the village limits and remain conjoined to the hamlet of Collins, where NY 39 leaves US 62 on Main Street.

As it heads north, US 62 passes by the Erie County Fairgrounds and Hilbert College and crosses over the New York State Thruway (I-90) before intersecting with Southwestern Boulevard (US 20).

[10] North of US 20, US 62 parallels the Thruway northward to the village of Blasdell, located on the border of Hamburg and the city of Lackawanna.

The route continues onward through Blasdell and into Lackawanna, intersecting Ridge Road, an east–west arterial linking US 62 to NY 5 (Hamburg Turnpike), US 219 and the Thruway.

Just northwest of the Ridge Road junction are the Buffalo and Erie County Botanical Gardens, situated on the Lackawanna side of the Lackawanna–Buffalo city line.

[12] North of these junctions, the road passes through the city's industrial East Side, then back into residential neighborhoods where it intersects Broadway, the western terminus of NY 130.

After the densely developed neighborhoods where Walden Avenue and Genesee Street intersect, it crosses under the Kensington Expressway (NY 33), where other local roads provide access.

US 62 continues north through heavily suburban territory to the junction with Sheridan Drive (NY 324), a major commercial strip across Buffalo's northern suburbs, where it leaves Bailey Avenue and heads west for a half-mile (0.8 km) to another major junction, Niagara Falls Boulevard, at the Amherst–Tonawanda town line,[12] where it turns north again, following the Boulevard (as it is locally known) past Boulevard Mall at the junction with Maple and Brighton Roads, then through another commercial strip to I-290.

A short distance further on, as Tonawanda Creek starts to run parallel to the highway, all the land to the west becomes part of Amherst.

West of NY 182, US 62 dips southwest and enters the city of Niagara Falls,[13] where US 62 initially passes by a mixture of commercial and residential developments, then meets NY 265 (Military Road) in the easternmost part of the city ahead of a junction with I-190 exit 22, a mile (1.6 km) to the west.

Upon intersecting Packard Road, a local northeast–southwest arterial situated just east of Pine Avenue, US 62 splits into a one-way couplet to serve the residential portion of downtown Niagara Falls.

US 62 travels into the city (northbound) on Walnut Avenue and out (southbound) on Ferry Avenue and both intersect Hyde Park Boulevard (NY 61) near the eastern end of the couplet, which continues west for roughly 1.75 miles (2.82 km) to NY 104 (Main Street), where US 62 terminates northeast of the city's tourism district and the Rainbow Bridge to Canada.

The two routes then overlapped NY 5 southwest on Main Street for roughly 0.5 miles (0.8 km) to reach Niagara Falls Boulevard.

[1] Farther north in Niagara Falls, US 62 was shifted south in the mid-1960s from Pine Street onto Walnut and Ferry avenues, which had been transformed into a one-way couplet.

It runs east–west for 2.12 miles (3.41 km) along Pine Avenue from NY 104 in downtown Niagara Falls to US 62 east of the city center.