The street heads east through the town of Cheektowaga to an intersection with Harlem Road (NY 240), where Walden Avenue widens from two to four lanes and takes on a suburban commercial setting.

It continues generally eastward past smaller commercial establishments to New York State Thruway (I-90) exit 52, where the highway widens to six lanes in advance of the sprawling Walden Galleria shopping mall, located adjacent to the northeastern corner of the interchange.

[citation needed] East of the village of Lancaster, the development along Walden Avenue begins to taper off as the constant homes and businesses slowly give way to large stretches of wooded areas.

Still, the highway initially passes several cul-de-sacs leading away from the northern side of the road and a number of industrial buildings situated adjacent to the CSX mainline, here designated as the Rochester Subdivision line.

It passes north of the Wende Correctional Facility and serves a small number of commercial and industrial complexes on its way to an intersection with Genesee Street (NY 33).