The club was founded on 3 November 1903, and is named after Isaac Newell of the English county of Kent, one of the pioneers of Argentine football.

[4] Other sports practised at this club are basketball, boxing, field hockey, martial arts, roller skating, volleyball and American football.

Newell called teachers, pupils and alumni of the school his father had established to sign the act of foundation of the club.

In fact, the players of the first football team were graduates of the school Isaac Newell had established, the Colegio Comercial Anglicano Argentino.

Other trophy were teams of both cities played together was the Copa Dr. Carlos Ibarguren, won by Newell's in 1921, defeating Huracán by 3–0.

Despite playing in the national tournaments, Newell's continued participating in the regional leagues of Rosario, but with youth amateur players.

The line-up was: Heredia; Gilli, Soneyro; Sisniega, Perucca, Reynoso; Belén, Fabrini, Gómez, Franco, Sánchez.

Newell's Old Boys have won the Primera División championship six times (1974 Metropolitano, 1987–88, 1990–91, 1992 Clausura, Apertura 2004 and 2013 Final) and were the runners-up of the Copa Libertadores de América twice (1988 and 1992).

Newell's also won a friendly youth mini-tournament called the Little World Cup in 1988, against River Plate, Milan, Juventus, Real Madrid and Manchester United, and is, together with Boca Juniors, San Lorenzo and Racing Club one of the few Argentine clubs that made a long and successful tour in Europe (in 1949), in which they defeated several important teams such as Valencia, Borussia Mönchengladbach, Real Madrid and the Spanish National "A" Team.

Among its great players were Gabriel Batistuta, Abel Balbo, Jorge Valdano, Américo Gallego, Mario Zanabria, Gustavo Dezotti, Roberto Sensini, Walter Samuel, Mauricio Pochettino, René Pontoni, Gerardo Martino, Ángel Perucca and several more.

The black and red colors used in the coat were extracted from the flags of England (where Newell was born) and the German Empire (country of origin of his wife, Anna Jockinsen).

[10] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.