It is the primary highway on the island, connecting all of the island's communities with the MV Veteran ferry, which in turn connects them to mainland Newfoundland and the rest of Canada.

Route 333 begins in Stag Harbour at the island's ferry terminal on the western edge of town.

It heads east to pass through town before leaving and winding its along the southern coast for several kilometres.

The highway now passes through Seldom-Little Seldom, where it turns due north, and heads inland for several kilometres to pass by the Fogo Aerodrome, where it has an intersection with Island Harbour Road, which provides access to Island Harbour and Deep Bay.

The highway now heads northwest through rural areas for several kilometres to the island's northern coast to enter Fogo, where it comes to an end at an intersection with Main Street just east of downtown.