From there, the highway crosses the island 903 kilometres (561 mi) to Channel-Port aux Basques, its western terminus.

From there, the Trans-Canada Highway is carried across the Cabot Strait by ferry to North Sydney, Nova Scotia.

Route 1's official eastern terminus is at the interchange with Logy Bay Road in the northeastern part of the city.

Route 1 transitions to a 2-lane controlled access highway and continues northwest from Whitbourne along the isthmus of the Avalon Peninsula and 188 km north to Glovertown, bypassing Clarenville, small communities like Arnold's Cove, Goobies and passing through Terra Nova National Park; park admission is not required to use Route 1.

From Glovertown, the highway proceeds northwest 182 km to Badger, bypassing Gander, Glenwood.

The Isles of Notre Dame region of the province, which includes Fogo, the Twillingate Islands, New World Island and surrounding areas, can be accessed via Route 340 at the Notre Dame Junction [fr] interchange near Lewisporte.