Route 345 is a 16.1-kilometre-long (10.0 mi) north-south highway on New World Island in the Canadian province of Newfoundland and Labrador.

It connects the communities of Virgin Arm–Carter's Cove with Tizzard's Harbour on the western half of the island.

It winds its way west through town before leaving and heading northwest through rural areas to pass through Chanceport.

The highway now winds its way through wooded and hilly terrain for several kilometres to come to an intersection with a spur road leading to Bridgeport, where it turns north to enter Moreton's Harbour.

It heads northeast through rural areas for several more kilometres to enter Tizzard's Harbour, where it comes to an end at the centre of town.