Route 350 continues on from Point Leamington for another 25 km north to Leading Tickles where the road officially ends.

Along the way there is another short road connecting Glovers Harbour to the main route as well.

The highway begins following the coastline of the Bay of Exploits as it passes through Botwood, where it meets a local road leading to Peterview, and Northern Arm, where it makes a left turn at an intersection with Route 352 (Fortune Harbour Road).

Route 350 now heads north through inland terrain for several kilometres to Point Leamington, where it meets a local road leading to Pleasantview before winding its through town.

Route 350 passes through some neighbourhoods before crossing a Causeway onto Cull Island and heading westward through the main part of town.