The area was occupied in the Viking Jorvik period, and excavations in 1963 found a 10th-century cross shaft.

[2][3] In the 1750s, the early Methodists in the city often met upstairs at number 6 Newgate, and John Wesley preached there twice.

[4] From 1952, a new marketplace for the city was created immediately south of the street, originally named "Newgate Market", but now known as Shambles Market, and this entailed the demolition of several buildings on the south side of the road.

All the surviving ones with Newgate street addresses lie on its northern side.

6 Newgate was largely rebuilt in 1963, but its ground floor has some Mediaeval masonry, including a Perpendicular window.