The Grade II listed building, formerly Hirst's studio, was awarded the RIBA Stirling Prize following its conversion in 2016 by Caruso St John Architects.

[7] The gallery spans 37,000 square feet (3,400 m2) and includes six exhibition spaces – one with a ceiling height of 11 metres (36 ft) – split over two levels.

The Murderme collection, which Hirst has been acquiring since the late 1980s, contains over 3,000 works and features art by Francis Bacon, Banksy, Tracey Emin, Richard Hamilton, Jeff Koons, Sarah Lucas, Pablo Picasso, Richard Prince, Haim Steinbach and Gavin Turk, as well as a number of young and emerging artists such as Helen Beard, Sadie Laska and Boo Saville[8][9] and a significant collection of work by indigenous artists from the Pacific Northwest coast.

Also featured are natural history specimens, taxidermy, anatomical models and historical artefacts.

The collection was previously the subject of large-scale exhibitions at the Serpentine Gallery, London (2006) and the Pinacoteca Giovanni e Marella Agnelli, Turin (2013).