He was also a friend of Colin St John Wilson, the architect of the British Library, since they both participated in the This is Tomorrow exhibition at the Whitechapel Gallery in 1956.
It can be interpreted as symbolising a confluence of the two cultures, the arts and the sciences, and illustrating how Newton changed our view of the world to one determined by mathematical laws.
The sculpture makes the body resemble a mechanical object, joined with bolts at the shoulders, elbows, knees and ankles.
The sculptures shows the visible seams of Paolozzi's technique of dividing his model and reassembling the pieces, for example on the head.
A maquette was donated by the artist to the Isaac Newton Institute for Mathematical Sciences at the University of Cambridge.